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Index > Protein center > Chrna7(Gene name) > Rat
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  • Chrna7 (Gene name),
  • Neuronal acetylcholine receptor subunit alpha-7 (Protein name ),  ACHA7_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Chrna7(Acra7);
    Protein name:
    Neuronal acetylcholine receptor subunit alpha-7;
    Alternative:

    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Homopentamer. Interacts with RIC3; which is required for proper folding and assembly.
    Function:
    After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.
    Subcellular Location:
    Cell junction synapse postsynaptic cell membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    502
    Sequence:
    50:
    MCGGRGGIWL | ALAAALLHVS | LQGEFQRRLY | KELVKNYNPL | ERPVANDSQP | 
    100:
    LTVYFSLSLL | QIMDVDEKNQ | VLTTNIWLQM | SWTDHYLQWN | MSEYPGVKNV | 
    150:
    RFPDGQIWKP | DILLYNSADE | RFDATFHTNV | LVNASGHCQY | LPPGIFKSSC | 
    200:
    YIDVRWFPFD | VQQCKLKFGS | WSYGGWSLDL | QMQEADISSY | IPNGEWDLMG | 
    250:
    IPGKRNEKFY | ECCKEPYPDV | TYTVTMRRRT | LYYGLNLLIP | CVLISALALL | 
    300:
    VFLLPADSGE | KISLGITVLL | SLTVFMLLVA | EIMPATSDSV | PLIAQYFAST | 
    350:
    MIIVGLSVVV | TVIVLRYHHH | DPDGGKMPKW | TRIILLNWCA | WFLRMKRPGE | 
    400:
    DKVRPACQHK | PRRCSLASVE | LSAGAGPPTS | NGNLLYIGFR | GLEGMHCAPT | 
    450:
    PDSGVVCGRL | ACSPTHDEHL | MHGAHPSDGD | PDLAKILEEV | RYIANRFRCQ | 
    500:
    DESEVICSEW | KFAACVVDRL | CLMAFSVFTI | ICTIGILMSA | PNFVEAVSKD | 
    502:
    FA
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    UniGene:
    Pfam:
    String:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Rat Neuronal acetylcholine receptor subunit alpha-7
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    E9618h
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    96T
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    ELISA Kit for Rat Neuronal acetylcholine receptor subunit alpha-7
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    E9618r
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    ELISA Kit for Rat Neuronal acetylcholine receptor subunit alpha-7
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    E9618b
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    96T
    ELISA Kit for Rat Neuronal acetylcholine receptor subunit alpha-7
    Cat.:
    E9618c
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    Packing:
    96T
    ELISA Kit for Rat Neuronal acetylcholine receptor subunit alpha-7
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    E9618m
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    Packing:
    96T
    CLIA Kit for Rat Neuronal acetylcholine receptor subunit alpha-7
    Cat.:
    U9618r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Rat Neuronal acetylcholine receptor subunit alpha-7
    Cat.:
    U9618c
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Neuronal acetylcholine receptor subunit alpha-7
    Cat.:
    U9618b
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Neuronal acetylcholine receptor subunit alpha-7
    Cat.:
    U9618m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Neuronal acetylcholine receptor subunit alpha-7
    Cat.:
    U9618h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Rat Neuronal acetylcholine receptor subunit alpha-7
    Cat.:
    P9618Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Neuronal acetylcholine receptor subunit alpha-7
    Cat.:
    P9618Rb-m
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    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Neuronal acetylcholine receptor subunit alpha-7
    Cat.:
    P9618Rb-r
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    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Neuronal acetylcholine receptor subunit alpha-7
    Polyclonal Antibody for Rat Neuronal acetylcholine receptor subunit alpha-7
    Monoclonal Antibody for Rat Neuronal acetylcholine receptor subunit alpha-7
    Monoclonal Antibody for Rat Neuronal acetylcholine receptor subunit alpha-7
    Monoclonal Antibody for Rat Neuronal acetylcholine receptor subunit alpha-7
    Monoclonal Antibody for Rat Neuronal acetylcholine receptor subunit alpha-7
    Monoclonal Antibody for Rat Neuronal acetylcholine receptor subunit alpha-7
    Protein for Rat Neuronal acetylcholine receptor subunit alpha-7
    Protein for Rat Neuronal acetylcholine receptor subunit alpha-7
    Protein for Rat Neuronal acetylcholine receptor subunit alpha-7
    Protein for Rat Neuronal acetylcholine receptor subunit alpha-7
    Protein for Rat Neuronal acetylcholine receptor subunit alpha-7

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Molecular cloning, functional properties, and distribution of rat brain alpha 7: a nicotinic cation channel highly permeable to calcium."
      Seguela P. , Wadiche J. , Dineley-Miller K. , Dani J.A. , Patrick J.W.
      J. Neurosci.13:596-604(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Brain.
    2. 2.
      Boulter J.
      Submitted (1994-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: Sprague-Dawley.
      tissue: Brain.
    3. 3.
      Hartley M.
      Submitted (1998-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION TO 363
      strain: Sprague-Dawley.
      tissue: Brain.
    4. 4.
      Groot-Kormelink P.J.
      Submitted (2004-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: Sprague-Dawley.
      tissue: Brain.
    5. 5.
      "Dual role of the RIC-3 protein in trafficking of serotonin and nicotinic acetylcholine receptors."
      Castillo M. , Mulet J. , Gutierrez L.M. , Ortiz J.A. , Castelan F. , Gerber S. , Sala S. , Sala F. , Criado M.
      J. Biol. Chem.280:27062-27068(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RIC3;MUTAGENESIS OF LEU-433; LYS-435; VAL-440; ASN-445; ARG-446; PHE-447 AND ARG-448
    6. 6.
      "RIC-3 enhances functional expression of multiple nicotinic acetylcholine receptor subtypes in mammalian cells."
      Lansdell S.J. , Gee V.J. , Harkness P.C. , Doward A.I. , Baker E.R. , Gibb A.J. , Millar N.S.
      Mol. Pharmacol.68:1431-1438(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RIC3
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